The crash was reported at the intersection of state Route 4 and Moorefield Road around 9 a.m.
Firefighters said one person was flown to an area hospital with serious injuries, but their condition was not immediately known.
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Two others were transported by ground ambulances and their conditions were also unknown.
The crash shut down state Route 4 into the late morning but all lanes were reopened before 11:30 a.m.
State troopers are investigating the crash and additional details were not released.
We’ll continue to update this story as we learn more.
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