The game was tied with 7:18 to play after a jump shot by Jake Bertemes. Guilford started an 8-0 run on its next possession. The Tigers didn’t score again until a layup by Rashaad Ali-Shakir with 3:21 to play.
Wittenberg cut the deficit to 61-58 on a 3-pointer by Mitch Balser at the 2:28 mark. Then Guilford scored the next seven points to clinch the victory.
Three-point shooting hurt Wittenberg. It matched its season season-high with 34 attempts and made nine of them (26.5 percent) after topping 40 percent in five of its previous six games.
James Johnson led Wittenberg with 15 points on 4-of-10 shooting. He had eight points in the first eight minutes.
Jake Bertemes scored 13 points on 6-of-13 shooting. Connor Seipel made 5 of 7 shots and scored 10 points. Ali-Shakir had nine points off the bench. Balser, Wittenberg’s only senior, scored six points in his final game.
Guilford (23-7) advanced to face No. 13 St. Thomas in the Sweet 16.
» EARLIER COVERAGE: Wittenberg confident after recent success on road
First-round game: Wittenberg beat No. 18 Emory 100-88 in the first round Friday. Bertemes led the Tigers with 22 points.
Seipel added 21 and passed the 1,000-point mark in his career. He ended his junior season with 1,028 points. He’s the 32nd player in Wittenberg history to reach the milestone.
Johnson scored 20. Ali-Shakir had 13.
The Tigers made 11 of 20 3-pointers (55 percent) and shot 59.3 percent from the field.
Wittenberg ended the first half on an 18-8 run to take a 51-41 halftime lead and pushed its lead into double digits midway through the second half.