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Without Young and Cooper, Ohio State lists freshmen Javontae Jean-Baptiste and Zach Harrison as the starter at one end spot with sophomores Tyler Friday and Tyreke Smith sharing the other side.
Tyreke Smith and Zach Harrison both got to the Maryland quarterback on Saturday
Last week, tight end Rashod Berry also saw time on defense to help fill the void.
Baron Browning, the co-starter at middle linebacker with Tuf Borland and a member of multiple sub-packages on defense, is also unavailable, as are backup offensive linemen Josh Alabi and Matthew Jones.
True freshman Enokk Vimahi is listed as the backup right guard with Jones out of the depth chart.
Marcus Crowley, a freshman running back who left last week’s game late with an apparent leg injury, is also out along with a handful of players who have not played all season because of injuries.