Wyche was controversial for his innovations on offense. Wyche started using the no-huddle during regular game situations, which the NFL banned during the 1988 AFC Championship game. He also used various trick plays and several types of huddles and quick counts to gain advanages on offense. An emotional coach, Wyche collided with other coaches, most notably Houston Oilers coach Jerry Glanville, who he had a feud with for years. He drew the ire of Cleveland fans during a game agains the Seattle Seahawks in 1989. Fans angry with a late game call by the refs began throwing snowballs onto the field. Wyche took the Riverfront Stadium microphone and delivered the infamous line,"Wlll the next person who sees anybody throwing anthing onto this field, point them out, get them out of here. You don't live in Cleveland, you live in Cincinnati."
After winning the division in 1990, the team finished last and won only three games in 1991. Original owner and hall of fame coach Paul Brown had died in 1990, leaving conrol of the franchise to his son Mike. Wyche and Mike Brown got into an argument during a meeting after the season in which Brown said Wyche had quit, while Wyche claimed he was fired. Many speculated Brown said Wyche quit so they wouldn't have to pay him the remainder of his contract.
Wyche coached the Tampa Bay Buccaneers for four years during the mid 1990s. He spent time as a color commentator and studio analyst and was quarterback coach with the Buffalo Bills in 2004-05. He volunteered as an offensive coordinator for a local high school team, was a substitute teacher and also ran for Ccounty Council in South Carolina in 2008.