She said that in some emails, Ramos suggested she kill herself.
"I don't know what he wanted," she told NBC News. "He never asked for my phone number. He never asked to call me. You know he never asked to meet me."
Ramos was charged with criminal harassment after Lori filed a report with police. He pleaded guilty in July 2011, according to NBC News.
The case was at the center of the dispute between Ramos and staffers at the Capital Gazette newsroom. Thomas Marquardt, the newspaper's former editor and publisher, told The Baltimore Sun that Ramos started to harass staff members shortly after a columnist wrote an article in 2011 about the harassment case. The columnist, Eric Hartley, no longer works at the paper.
Ramos sued Harley, the Capital Gazette and Marquardt for defamation in 2012, but a judge dismissed the case.
Anne Arundel County police Chief Timothy Altomare said Friday that the Capital Gazette declined to press charges against Ramos after he made threats against the newspaper on social media in 2013.
“There was a fear that doing so would exacerbate an already flammable situation,” he said.
Lori told NBC News that she knew Ramos was behind last week's attack after police said in the immediate aftermath of the shooting that they could not identify the suspect.
“As soon as they said it happened at The Capital newspaper and they couldn’t identify their suspect, I picked up the phone and said, ‘I know who your suspect is,’” she said. “I knew if he was to do anything on a mass shooting level, it was going to target The Capital.”
Marquardt told the Sun he called police about Ramos's threats in 2013.
“I remember telling our attorneys, 'This is a guy who is going to come in and shoot us,’” he said.
Altomare said Ramos was armed with a 12-guage, pump-action shotgun when he showed up Thursday afternoon at the Capital Gazette offices in Maryland.
“The fellow was there to kill as many people as he could kill,” Altomare said.
Police arrested Ramos on Thursday after finding him hiding under a table at the Capital Gazette offices. He was charged with five counts of first-degree murder.
A judge ordered him held without bail Friday.