The show, broadcast live from Los Angeles, will honor professional and amateur athletes and others who contribute to the sports scene.
One of those people is Rob Mendez, who will receive the Jimmy V Perseverance Award. Mendez, a high school football coach, was born without arms and legs.
The award was named for former North Carolina State Basketball coach Jim Valvano, who died from cancer in 1993.
NBA legend Bill Russell, 85, will be honored with the Arthur Ashe Courage Award. Russell holds the record for most NBA championships won by a single player, but, he is being honored for his support of civil rights causes.
Members of the U.S. women's soccer team will also make an appearance at the ceremony. They will fly in for The ESPYs in L.A. after a ticker-tape parade in New York on Wednesday morning.
Here’s what you need to know about the show.
What time is it on?
The ceremony begins at 8 p.m. ET on Wednesday.
Where is it being held?
The 2019 ESPY Awards will take place at the Microsoft Theater in Los Angeles.
The awards show will air live on ABC.
Live streaming and social media?
Who is hosting?
Comedian Tracy Morgan will host the 2019 ESPY Awards. "I am very excited to be hosting the ESPYs,” Morgan said in a statement. “I hope my Uncle Sidney Poitier is there with my biological father Tony Dorsett and my second cousin Herschel Walker. And Bo Jackson, I want my two dollars back!"
Who is nominated?
Serena Williams, Tiger Woods, Naomi Osaka, Simone Biles and many others are on the list of nominees.
A full list of this year's nominees is available here.