With Baltimore ahead 2-0 in the second, Chisholm hit a two-out double off Dean Kremer and went home on DJ LeMahieu's single to left.
Colton Cowser's throw was up the third-base line. Handley moved to his left for the throw, arriving for the ball at the same time as Chisholm, who tried to veer to the inside to avoid contact.
Chisholm, whose left cleat had come off as he speeded down the line, caught Handley with his right arm, fell past the plate and had to come back to touch it.
Handley, a 27-year-old who debuted in April, got up slowly and was removed after a discussion with Masolino and head athletic trainer Scott Barringer. Baltimore replaced Handley with former Yankees player Gary Sánchez.
Baltimore already is without All-Star catcher Adley Rutschman, who strained his left oblique and is on the injured list for the first time in his major league career.
After San Francisco All-Star catcher Buster Posey sustained a season-ending leg injury in May 2011, Major League Baseball ahead of the 2014 season adopted a rule preventing catchers from blocking a runner's direct path to the plate without the ball.
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AP baseball: https://apnews.com/MLB
Credit: AP
Credit: AP
Credit: AP
Credit: AP