"She's been there for 30 years and has never done anything for you or your family," as he accused Clinton of focusing only on "small and petty distractions" in her campaign.
Trump appeared in New Hampshire a day after Hillary Clinton had been there for a joint rally with Sen. Bernie Sanders; Trump openly mocked their campaign efforts.
"Very, very small crowd," Trump said. "Very, very sad."
"The people of New Hampshire - and everywhere else - don't care about Bernie anymore," Trump added.
But while Trump has made gains in a number of swing states, he has not been able to get ahead of Clinton in New Hampshire.
In his speech, Trump also turned some fire on Clinton's husband, without mentioning former President Bill Clinton's name.
"And impeachment for lying, impeachment for lying - remember that?" Trump asked at one point, arguing that the Clintons are all about controversy and scandal.
"The American people have had it with years and decades of Clinton corruption and scandal," Trump said to cheers, as he cast himself as the outsider who would clean things up in D.C.
"The Clintons are the sordid past, we will be the very bright and clean future," Trump said.
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