One Republican, Susan Collins of Maine, voted against the President's nominee.
As for Democratic critics, they saw something much darker with the approval of Pruitt, who led a number of state attorneys general in lawsuits against the EPA.
"Pruitt cares more about protecting Big Oil than protecting our planet," said Sen. Bob Menendez (D-NJ).
"Donald Trump has made clear his job, his goal is to degrade, destroy the Environmental Protection Administration," said Sen. Tom Carper (D-DE), as he led a parade of Democrats who criticized Pruitt for his views on climate change and more.
Republicans had hoped to approve Pruitt and four other Trump nominations that are awaiting final Senate votes, but Democrats refused to allow them to move forward, leaving Republicans frustrated.
"It has led what is now the longest it has taken to confirm most of a President's Cabinet since - George Washington," said Senate Majority Leader Mitch McConnell.
"What a record!" McConnell said in a mocking tone on the Senate floor, as he said it's time for Democrats to stop their delays.
"Enough is enough," the Majority Leader said.
On hold for now are the nominations of Wilbur Ross for Commerce Secretary, Rep. Ryan Zinke (R-MT) for Interior Secretary, Ben Carson for Secretary of Housing and Urban Development, and Rick Perry for Energy Secretary.
Sen. McConnell could have chosen to keep the Senate in session into the weekend and next week to force debate and final votes on those four nominations - here is what that theoretical type of schedule would have looked like:
1:30 pm - invoke cloture on Ross nomination; then 30 hours of debate
Saturday 7 pm - final vote on Ross nomination
7:30 pm - invoke cloture on Zinke nomination, then 30 hours of debate
Monday 2 am - final vote on Zinke nomination
2:30 am - invoke cloture on Carson nomination, then 30 hours of debate
Wednesday 9 am - final vote on Carson nomination
9:30 am - invoke cloture on Perry nomination, then 30 hours of debate
Thursday 4 pm - final vote on Perry nomination
So, you can see just how much time is consumed when one party wants to slow things down in the Senate.
If Democrats refuse to relent, then it will likely mean that the fight over this batch of four nominees will extend into March.
As for Pruitt, the Trump Administration wasted no time getting him on the job, as he was sworn in before the sun went down on Friday by Supreme Court Justice Samuel Alito.