The nominations that were approved were part of dozens that have been awaiting Senate action in recent months; most of those confirmed were not household names, and were not waiting to take jobs that would be known by people outside of Washington, D.C.
One of the few big names was Woody Johnson, the owner of the New York Jets, who will be the U.S. Ambassador to the United Kingdom.
Other ambassadors confirmed included those to Canada, Costa Rica and Portugal.
One that did not make the cut was Callista Gingrich, wife of former House Speaker Newt Gingrich, who was picked by Mr. Trump for the post of Ambassador to the Vatican.
It is not clear when Mrs. Gingrich - and about 40 other nominees who are still on the calendar - will get a vote, but it won't happen until after Labor Day.
Republicans made clear that they thought Democrats had gone too far by holding up so many nominees of the President.
"This was a big day," said Sen. John Cornyn (R-TX), the number two Republican in Senate, who said there was no reason for the "obstruction and foot dragging" of Democrats.