Day Day Thomas scored 10 points for Cincinnati (12-9, 2-8), which shot 31.5% (17 of 54) from the field and has lost four straight.
West Virginia built a double-digit lead about midway through the first half and led 40-25 at the break. Small made three 3-pointers and scored 14 points and had five assists to pace the Mountaineers.
Cincinnati pulled within 12 points, 45-33, with 14:03 remaining. West Virginia answered with a 14-4 run, capped by consecutive 3s from Yesufu, and the Mountaineers maintained their double-digit lead the rest of the way.
On Wednesday, West Virginia plays at TCU while Cincinnati is on the road against UCF.
__ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here. AP college basketball: https://apnews.com/hub/ap-top-25-college-basketball-poll and https://apnews.com/hub/college-basketball