Francona conducted his regular pregame media briefing via video conference from Target Field. The club announced his absence about an hour later. The 61-year-old Francona returned to the team hotel, and first base coach Sandy Alomar Jr. took over managing duty for the four-game series finale against the Twins.
Francona, who has experienced some gastrointestinal discomfort since spring training, was sent home with a visit to the Cleveland Clinic for further examination set for Monday morning. President of baseball operations Chris Antonetti said Francona could miss the next two games in Cincinnati.