The “Fuller House” star shared the news with fans on Instagram with a cartoon drawing of himself and McHugh at Disneyland.
“I asked … she said yes! …And we lived happily ever after,” he wrote in the caption.
Stamos, 54, first revealed he was off the market during a 2016 appearance on “The View,” according to PEOPLE magazine.
McHugh, 31, has also been vocal about the love and support she receives from her leading man.
“He’s very encouraging of anything I want to do career-wise,” she told Entertainment Tonight earlier this year. “I really appreciate it a lot. You don’t get that with every guy.”
Stamos and McHugh acted as colleagues this year while completing a film together, “Ingenueish,” which Stamos directed and McHugh starred in. McHugh is also known for roles in “The Vampire Diaries” and “Switched at Birth,” and she made her silver screen debut in Will Smith’s “I Am Legend.”
Stamos was previously married to Rebecca Romijn from 1998 to 2005.