According to WSOC-TV, the man, identified as 43-year-old Keith Lamont Scott, was taken to Carolinas Medical Center, where he was pronounced dead.
Police said the officer involved in the shooting was Brentley Vinson. As is standard procedure with any officer-involved shooting, Vinson has been placed on paid administrative leave, police said. Vinson has been employed with the CMPD since July 21, 2014.
Detectives recovered a firearm at the scene that they said the man had been holding when he was shot.
>> Read more trending stories
Scott's relatives said he did not have a gun, but instead had a book in his hand and was waiting for his son to be dropped off from school.
Tuesday night, protesters gathered in the streets chanting, "Black lives matter," and "Hands up, don't shoot!" Some protesters reportedly damaged police cruisers, and police deployed tear gas into the crowd.
Early Wednesday, protesters reportedly blocked I-85. Meanwhile, people were seen lighting fires and looting trucks and a local Walmart.
For the latest on this developing story, visit WSOC-TV's website or follow WSOC on Twitter.
– The Associated Press and the Cox Media Group National Content Desk contributed to this report.
>> Click here or scroll down for the latest updates from the scene