In a separate study, they evaluated mice with a condition comparable to Alzheimer’s disease and arthritis. They said the rodents with Alzheimer’s responded to lower doses of the opioid-based morphine, compared with those without the disorder. Those with the condition also suffered worse side effects and produced more of the body’s natural endogenous opioids such as endorphins.
In another assessment, they focused only on so-called Z-drugs, a group of medicines including zolpidem, zopiclone and zaleplon. The team analyzed the data for 2,952 people with dementia prescribed the medication and data for 1,651 who were not.
They discovered that people who took Z-drugs were more likely to fracture a bone, compared with those who didn’t take them. Bone fractures are related to an increased risk of death in people with dementia.
"Research into antipsychotics highlighted that they increased harmful side effects and death rates in people with dementia. This compelling evidence base helped persuade everyone involved in the field to take action, from policy makers to clinicians, reducing prescribing by 50 percent," co-author Clive Ballard said in statement. "We now urgently need a similar concerted approach to opioid-based painkillers and Z-drugs, to protect frail elderly people with dementia from fractures and increased risk of death."
Researchers now hope to continue their investigations to determine whether adjusting the dosage of painkillers given to those with dementia can reduce dangerous side effects.