Prosecutors believe that Cameron pulled a gun out of an ankle holster and shot his wife in the head.
After Cameron shot his wife, he ordered the driver to keep driving down the road.
Police eventually found Cameron blocks away from the crime scene.
"The execution and the style of manner that this was done gives the state grave concern," said a prosecutor.
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Cameron didn't speak in court on Monday, not even when the judge set his bond at $3 million.
"It was Mr. Espitia in the back seat with the wife in the front passenger seat, and a gunshot to the back of her head killing her,” said a prosecutor.
A local business owner, Menge Ayele, told KIRO 7 that the Uber driver visits his shop in Seattle frequently.
“It was horrible ... This is very unfortunate and very sad. And we really feel horrible about this,” said Ayele.
KIRO 7 has learned that Cameron and Jennifer had been married for a few years and lived 10 miles away from the crime scene.
A college friend, who was at their wedding in Capitol Hill, described Jennifer as very pleasant, happy and fun.
Pictures posted on social media show Jennifer by Cameron’s side as Cameron underwent heart surgery in the past.
Cameron is in jail on suicide watch.