Perry's absence didn't deter most concert goers, but he was clearly part of the appeal of coming to the show.
"We've seen Alice Cooper three times, and, of course, Johnny Depp – we love his movies," said Chris Stacy, speaking about herself and husband Mark.
"And Aerosmith, well, they've been on our bucket list," the Beavercreek woman said.
The Hollywood Vampires take their name from a 1970s celebrity drinking club formed by Cooper that included other musicians, such as Keith Moon of The Who. The band's set list honors a number of Cooper's rock musician friends who died untimely deaths due to the excessive lifestyle that's a hallmark of rock 'n' roll superstardom.
"The fact that they'd doing a tribute to all of their dead friends is great," Mark Stacy said.
PHOTOS: Hollywood Vampires at Fraze Pavilion
Accustomed to starring in leading roles in the movies, Johnny Depp was almost unassuming as he played guitar and sang backing vocals. Other band members included Stone Temple Pilot's Robert DeLeo on bass and Guns N' Roses' Matt Sorum on drums. But it was clear to everyone in the audience that the star of the evening was the 68-year-old Cooper, who sang lead on every song.
A consummate singer and songwriter, Cooper is known as the godfather of "shock rock," whose shows typically include snakes, electric chairs, straight jackets and guillotines. With The Hollywood Vampires, he has reinvented himself. He showed off his pipes in numbers ranging from David Bowie's "Suffragette City" to Led Zeppelin's "Whole Lotta Love" to Aerosmith's "Sweet Emotion."
"If we didn't do one of your favorite covers tonight, it's because they're not dead yet," Cooper told the audience.
The show's message was a mix of rock-while-you-can carpe diem as well as a reminder of the dangers of living on the edge.
Perry's publicist has reported that the guitarist "will rejoin his fellow Vampires on stage again soon."